Anti-inflammatory reflex action of splanchnic sympathetic nerves is distributed across abdominal organs
Davide Martelli, David GS Farmer, Michael J McKinley, Song T Yao, Robin M McAllen
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2019
The splanchnic anti-inflammatory pathway has been proposed as the efferent arm of the inflammatory reflex. Although much evidence points to the spleen as the principal target organ where sympathetic nerves inhibit immune function, a systematic study to locate the target organ(s) of the splanchnic anti-inflammatory pathway has not yet been made. In anesthetized rats made endotoxemic with lipopolysaccharide (LPS, 60 µg/kg iv), plasma levels of tumor necrosis factor-α (TNF-α) were measured in animals with cut (SplancX) or sham-cut (Sham) splanchnic nerves. We confirm here that disengagement of the splanchnic anti-inflammatory pathway in SplancX rats (17.01 ± 0.95 ng/ml, mean ± SE) strongly enha..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by Project Grant 1098887 from the National Health and Medical Research Council of Australia and from the Victorian Government Operational Infrastructure Support Program to Florey Institute of Neuroscience and Mental Health.