Journal article
Utility of Different Blood Pressure Measurement Components in Childhood to Predict Adult Carotid Intima-Media Thickness: The i3C Consortium Study
J Koskinen, M Juonala, T Dwyer, A Venn, J Petkeviciene, I Čeponienė, L Bazzano, W Chen, MA Sabin, TL Burns, JSA Viikari, JG Woo, EM Urbina, R Prineas, N Hutri-Kähönen, A Sinaiko, DR Jacobs, J Steinberger, S Daniels, O Raitakari Show all
Hypertension | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019
Abstract
Childhood blood pressure (BP) levels predict adult subclinical atherosclerosis. However, the best childhood BP component for prediction has not been determined. This study comprised 5925 participants aged 3 to 18 years from 6 cohorts who were followed into adulthood (mean follow-up 25.8±6.2 years). Childhood BP was measured by using a standard mercury sphygmomanometer in all cohorts. Study-specific carotid intima-media thickness ≥90th percentile was used to define subclinical atherosclerosis. Per SD change in the predictor, childhood systolic BP (SBP; age- and sex-adjusted odds ratio [95% CI], 1.24 [1.13-1.37]), mean arterial pressure (1.10 [1.07-1.13]), and pulse pressure (1.15 [1.05-1.27])..
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Awarded by National Institutes of Health
Funding Acknowledgements
This study was supported by a grant from the US National Institutes of Health (NIH/National Heart, Lung and Blood Institute [NHLBI]) number R01 HL121230 and the Australian National Health and Medical Research Council Project Grant (APP1098369 and APP211316). C.G. Magnussen was supported by a National Heart Foundation of Australia Future Leader Fellowship (100849). The Young Finns has been financially supported by the Academy of Finland (grants 126925, 121584, 124282, 129378, 117787, and 41071), the Social Insurance Institution of Finland; Kuopio, Tampere, and Turku University Hospital Medical Funds, Juho Vainio Foundation, Paavo Nurmi Foundation, Finnish Foundation of Cardiovascular Research, Finnish Cultural Foundation, Sigrid Juselius Foundation, Yrjo Jahnsson Foundation. J. Koskinen was supported by Turku University foundation (11-2259), Emil Aaltonen Foundation and Urmas Pekkala Foundation. The Muscatine Study was supported by a Specialized Center of Research (SCOR) in Atherosclerosis grant from the NHLBI HL-14230, by RR-00059 from the General Clinical Research Centers Program, NCRR, NIH, and by the following NHLBI (NHLBI) R01s HL-48050, HL-54730, and HL-61857. The Kaunas Cardiovascular Cohort Study was supported by research grants from the Research Council of Lithuania (LIG-01/2012).