Journal article

Normal cerebral cortical thickness in first-degree relatives of temporal lobe epilepsy patients

Saud Alhusaini, Magdalena A Kowalczyk, Clarissa L Yasuda, Mira K Semmelroch, Marilise Katsurayama, Matheus Zabin, Tamires Zanao, Mateus H Nogueira, Marina KM Alvim, Victoria R Ferraz, Meng-Han Tsai, Mary Fitzsimons, Iscia Lopes-Cendes, Colin P Doherty, Gianpiero L Cavalleri, Fernando Cendes, Graeme D Jackson, Norman Delanty

NEUROLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019

Abstract

OBJECTIVE: To examine cerebral cortex thickness in asymptomatic first-degree relatives of patients with mesial temporal lobe epilepsy (MTLE). METHODS: We investigated 127 asymptomatic first-degree relatives of patients with MTLE due to hippocampal sclerosis (HS) (mean age ± SD = 39.4 ± 13 years) and 203 healthy control individuals (mean age ± SD = 36.0 ± 11 years). Participants underwent a comprehensive clinical evaluation and structural brain MRI at 3 study sites. Images were processed simultaneously at each site using a surface-based morphometry method to quantify global brain measures, hippocampal volumes, and cerebral cortical thickness. Differences in brain measures between relatives of..

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Grants

Awarded by Science Foundation Ireland Research Frontiers Programme award


Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by Brazilian Institute of Neuroscience and Neurotechnology (BRAINN)


Awarded by National Council for Scientific and Technological Development (CNPq)


Awarded by NHMRC practitioner fellowship


Funding Acknowledgements

This work was supported by Science Foundation Ireland Research Frontiers Programme award (08/RFP/GEN1538), the National Health and Medical Research Council (NHMRC) of Australia (program grant 628952), the Brazilian Institute of Neuroscience and Neurotechnology (BRAINN; Grant 2013/07559-3), Sao Paulo Research Foundation (FAPESP), and National Council for Scientific and Technological Development (CNPq) (Grant 403726/2016-6). G.D.J. was supported by an NHMRC practitioner fellowship (1060312). M.A.K. was supported by Melbourne Research Scholarship (University of Melbourne).