Journal article
Normal cerebral cortical thickness in first-degree relatives of temporal lobe epilepsy patients
S Alhusaini, MA Kowalczyk, CL Yasuda, MK Semmelroch, M Katsurayama, M Zabin, T Zanão, MH Nogueira, MKM Alvim, VR Ferraz, MH Tsai, M Fitzsimons, I Lopes-Cendes, CP Doherty, GL Cavalleri, F Cendes, GD Jackson, N Delanty
Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019
Abstract
To examine cerebral cortex thickness in asymptomatic first-degree relatives of patients with mesial temporal lobe epilepsy (MTLE).MethodsWe investigated 127 asymptomatic first-degree relatives of patients with MTLE due to hippocampal sclerosis (HS) (mean age ± SD = 39.4 ± 13 years) and 203 healthy control individuals (mean age ± SD = 36.0 ± 11 years). Participants underwent a comprehensive clinical evaluation and structural brain MRI at 3 study sites. Images were processed simultaneously at each site using a surface-based morphometry method to quantify global brain measures, hippocampal volumes, and cerebral cortical thickness. Differences in brain measures between relatives of patients and ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by Science Foundation Ireland Research Frontiers Programme award (08/RFP/GEN1538), the National Health and Medical Research Council (NHMRC) of Australia (program grant 628952), the Brazilian Institute of Neuroscience and Neurotechnology (BRAINN; Grant 2013/07559-3), Sao Paulo Research Foundation (FAPESP), and National Council for Scientific and Technological Development (CNPq) (Grant 403726/2016-6). G.D.J. was supported by an NHMRC practitioner fellowship (1060312). M.A.K. was supported by Melbourne Research Scholarship (University of Melbourne).