The relationship between the placental serotonin pathway and fetal growth restriction
Suveena Ranzil, David W Walker, Anthony J Borg, Euan M Wallace, Peter R Ebeling, Padma Murthi
BIOCHIMIE | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | Published : 2019
Fetal growth restriction (FGR) is a complex disorder of human pregnancy that leads to poor health outcomes in offspring. These range from immediate risks such as perinatal morbidity and stillbirths, to long-term complications including severe neurodevelopmental problems. Despite its relatively high global prevalence, the aetiology of FGR and its complications is not currently well understood. We now know that serotonin (5-HT) is synthesised in the placenta and is crucial for early fetal forebrain development in mice. However, the contribution of a disrupted placental 5-HT synthetic pathway to the pathophysiology of placental insufficiency in FGR and its significant fetal neurodevelopmental c..View full abstract
We wish to acknowledge the funding support from The Australian Institute for Musculo-Skeletal Science (AIMSS), The University of Melbourne, Victoria, Australia.