Stressing out the mitochondria: Mechanistic insights into NLRP3 inflammasome activation
Monica Yabal, Dale J Calleja, Daniel S Simpson, Kate E Lawlor
JOURNAL OF LEUKOCYTE BIOLOGY | WILEY | Published : 2019
Inflammasomes are multimeric protein complexes that induce the cleavage and release of bioactive IL-1β and cause a lytic form of cell death, termed pyroptosis. Due to its diverse triggers, ranging from infectious pathogens and host danger molecules to environmental irritants, the NOD-like receptor protein 3 (NLRP3) inflammasome remains the most widely studied inflammasome to date. Despite intense scrutiny, a universal mechanism for its activation remains elusive, although, recent research has focused on mitochondrial dysfunction or potassium (K+ ) efflux as key events. In this review, we give a general overview of NLRP3 inflammasome activation and explore the recently emerging noncanonical a..View full abstract
Awarded by National Health and Medical Research Council
This work was supported by a National Health and Medical Research Council Project grant 1145788 to K.E.L. and operational infrastructure grants through the Australian Government IRISS and the Victorian State Government OIS.