Journal article

Stressing out the mitochondria: Mechanistic insights into NLRP3 inflammasome activation

Monica Yabal, Dale J Calleja, Daniel S Simpson, Kate E Lawlor

JOURNAL OF LEUKOCYTE BIOLOGY | WILEY | Published : 2019

Abstract

Inflammasomes are multimeric protein complexes that induce the cleavage and release of bioactive IL-1β and cause a lytic form of cell death, termed pyroptosis. Due to its diverse triggers, ranging from infectious pathogens and host danger molecules to environmental irritants, the NOD-like receptor protein 3 (NLRP3) inflammasome remains the most widely studied inflammasome to date. Despite intense scrutiny, a universal mechanism for its activation remains elusive, although, recent research has focused on mitochondrial dysfunction or potassium (K+ ) efflux as key events. In this review, we give a general overview of NLRP3 inflammasome activation and explore the recently emerging noncanonical a..

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University of Melbourne Researchers