Hierarchically Structured Porous Poly(2-oxazoline) Hydrogels
Jodie N Haigh, Ya-mi Chuang, Brooke Farrugia, Richard Hoogenboom, Paul D Dalton, Tim R Dargaville
MACROMOLECULAR RAPID COMMUNICATIONS | WILEY-V C H VERLAG GMBH | Published : 2016
A new method for fabricating hydrogels with intricate control over hierarchical 3D porosity using microfiber porogens is presented. Melt electrospinning writing of poly(ε-caprolactone) is used to create the sacrificial template leading to hierarchical structuring consisting of pores inside the denser poly(2-oxazoline) hydrogel mesh. This versatile approach provides new opportunities to create well-defined multilevel control over interconnected pores with diameters in the lower micrometer range inside hydrogels with potential applications as cell scaffolds with tunable diffusion and transport of, e.g., nutrients, growth factors or therapeutics.
The authors are grateful to Kathleen Lava, Bart Verbraeken, and Rebecca Forster for PAOx samples and to the ATN-DAAD for their support.