Can We Produce Heparin/Heparan Sulfate Biomimetics Using "Mother-Nature" as the Gold Standard?
Brooke L Farrugia, Megan S Lord, James Melrose, John M Whitelock
MOLECULES | MDPI AG | Published : 2015
Heparan sulfate (HS) and heparin are glycosaminoglycans (GAGs) that are heterogeneous in nature, not only due to differing disaccharide combinations, but also their sulfate modifications. HS is well known for its interactions with various growth factors and cytokines; and heparin for its clinical use as an anticoagulant. Due to their potential use in tissue regeneration; and the recent adverse events due to contamination of heparin; there is an increased surge to produce these GAGs on a commercial scale. The production of HS from natural sources is limited so strategies are being explored to be biomimetically produced via chemical; chemoenzymatic synthesis methods and through the recombinant..View full abstract
Awarded by Australian Research Council
This work was supported by funding from the Australian Research Council under the Linkage Project (LP100100504) scheme.