Platelet interactions with polyurethane nanocomposites: effect of organic modifier terminal functionality
BL Farrugia, A Simmons, M Jasieniak, HJ Griesser, LA Poole-Warren
MATERIALS TECHNOLOGY | MANEY PUBLISHING | Published : 2014
Surface modification is a flexible approach for manipulating blood-material interactions with the advantage that many different forms of devices can be modified without changing the bulk material properties. This study hypothesises that organic modifiers (OMs) used to prepare silicates for incorporation into polyurethane (PU) nanocomposites can migrate and be expressed on the PU surface and directly affect biological interactions. Two OMs of equivalent chain length with COOH or CH3end groups were used, and their surface expression was measured. Results suggested that surface expression occurred only in nanocomposites with methyl modified silicates. Platelet adhesion to the CH3and COOH modifi..View full abstract
Awarded by Australian Research Council
The authors would like to acknowledge assistance from L. Ferris (GSBmE, UNSW) and J. Norman, K. Levick and S. Lim (EMU, UNSW). This project was funded from the Australian Research Council under the Discovery Project (grant no. DP0558561) scheme and a Faculty of Engineering Research Grant (UNSW). Financial assistance received for B. Farrugia from AMMRF TAP grant and an ASBTE travel grant is gratefully acknowledged.