Poly(2-oxazoline) Hydrogels for Controlled Fibroblast Attachment
Brooke L Farrugia, Kristian Kempe, Ulrich S Schubert, Richard Hoogenboom, Tim R Dargaville
BIOMACROMOLECULES | AMER CHEMICAL SOC | Published : 2013
Currently there is a lack of choice when selecting synthetic materials with the cell-instructive properties demanded by modern biomaterials. The purpose of this study was to investigate the attachment of cells onto hydrogels prepared from poly(2-oxazoline)s selectively functionalized with cell adhesion motifs. A water-soluble macromer based on the microwave-assisted cationic ring-opening polymerization of 2-methyl-2-oxazoline and 2-(dec-9-enyl)-2-oxazoline was functionalized with the peptide CRGDSG or controls using thiol-ene photochemistry followed by facile cross-linking in the presence of a dithiol cross-linker. The growth of human fibroblasts on the hydrogel surfaces was dictated by the ..View full abstract
We are grateful to Rebecca Dawson at QUT for collecting the skin samples and to Bernhard De Meyer from the Polymer Chemistry Research group at Ghent University for the DMTA measurements. K.K. is grateful to the Alexander von Humboldt foundation for financial support. U.S.S. is grateful to the Dutch Polymer Institute and JCSM.