Physico-chemical/biological properties of tripolyphosphate cross-linked chitosan based nanofibers
Soumi Dey Sarkar, Brooke L Farrugia, Tim R Dargaville, Santanu Dhara
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | ELSEVIER | Published : 2013
In this study, chitosan-PEO blend, prepared in a 15 M acetic acid, was electrospun into nanofibers (~78 nm diameter) with bead free morphology. While investigating physico-chemical parameters of blend solutions, effect of yield stress on chitosan based nanofiber fabrication was clearly evidenced. Architectural stability of nanofiber mat in aqueous medium was achieved by ionotropic cross-linking of chitosan by tripolyphosphate (TPP) ions. The TPP cross-linked nanofiber mat showed swelling up to ~300% in 1 h and ~40% degradation during 30 day study period. 3T3 fibroblast cells showed good attachment, proliferation and viability on TPP treated chitosan based nanofiber mats. The results indicate..View full abstract
Authors would like to acknowledge Dr. Mike Doran, Mr. Nantu Dogra, Mr. Preetam Guha Ray, and Dr. Anand Tadas for scientific help, and Mr. Pallab Datta and Ms. Paulomi Ghosh for proof-reading the manuscript. DST, Govt. of India (financial support), IIT Kharagpur and Queensland University of Technology (infrastructural facility) are acknowledged.