Journal article

Physico-chemical/biological properties of tripolyphosphate cross-linked chitosan based nanofibers

Soumi Dey Sarkar, Brooke L Farrugia, Tim R Dargaville, Santanu Dhara

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | ELSEVIER | Published : 2013

Abstract

In this study, chitosan-PEO blend, prepared in a 15 M acetic acid, was electrospun into nanofibers (~78 nm diameter) with bead free morphology. While investigating physico-chemical parameters of blend solutions, effect of yield stress on chitosan based nanofiber fabrication was clearly evidenced. Architectural stability of nanofiber mat in aqueous medium was achieved by ionotropic cross-linking of chitosan by tripolyphosphate (TPP) ions. The TPP cross-linked nanofiber mat showed swelling up to ~300% in 1 h and ~40% degradation during 30 day study period. 3T3 fibroblast cells showed good attachment, proliferation and viability on TPP treated chitosan based nanofiber mats. The results indicate..

View full abstract

University of Melbourne Researchers