An investigation into the effect of amphiphilic siloxane oligomers on dermal fibroblasts
Brooke L Farrugia, Daniel J Keddie, Graeme A George, Emily C Lynam, Michael A Brook, Zee Upton, Tim R Dargaville
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | WILEY | Published : 2012
This study investigates the effect of well-defined poly(dimethylsiloxane)-poly(ethylene glycol) (PDMS-PEG) ABA linear block co-oligomers on the proliferation of human dermal fibroblasts. The co-oligomers assessed ranged in molecular weight (MW) from 1335 to 5208 Da and hydrophilic-lipophilic balance (HLB) from 5.9 to 16.6 by varying the number of both PDMS and PEG units. In general, it was found that co-oligomers of low MW or intermediate hydrophilicity significantly reduced fibroblast proliferation. A linear relationship between down-regulation of fibroblast proliferation, and the ratio HLB/MW was observed at concentrations of 0.1 and 1.0 wt % of the oligomers. This enabled the structures w..View full abstract
Awarded by Australian Research Council
Contract grant sponsor: Australian Research Council's Discovery Projects funding scheme; contract grant number: project DP0877988The authors would like to acknowledge Dr. Na Li for determination of critical aggregation concentration data and Dr. Bronwyn Laycock for useful discussions. Additional funding through a Queensland Smart State Fellowship for Dr. Tim Dargaville is acknowledged from the Queensland Government, Tissue Therapies Ltd. and QUT.