The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies
Brooke L Farrugia, Megan S Lord, James Melrose, John M Whitelock
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY | SAGE PUBLICATIONS LTD | Published : 2018
Key events that occur during inflammation include the recruitment, adhesion, and transmigration of leukocytes from the circulation to the site of inflammation. These events are modulated by chemokines, integrins, and selectins and the interaction of these molecules with glycosaminoglycans, predominantly heparan sulfate (HS). The development of HS/heparin mimetics that interfere or inhibit the interactions that occur between glycosaminoglycans and modulators of inflammation holds great potential for use as anti-inflammatory therapeutics. This review will detail the role of HS in the events that occur during inflammation, their interaction and modulation of inflammatory mediators, and the curr..View full abstract
Awarded by Australian Research Council
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by funding from the Australian Research Council under the Linkage Project (LP140101056) scheme.