Thesis / Dissertation

Studies on mechanisms of cell death in retinal degeneration

Kiana Kakavand, Robb de Iongh, Erica Fletcher, Andrew Jobling

Published : 2019

Abstract

Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinopathies affecting approximately 1.5 million people worldwide. RP is associated with genetic mutations leading to progressive deterioration of the photoreceptors followed by degeneration of the retinal pigment epithelium (RPE). The molecular mechanisms by which these mutations drive photoreceptors to death are not well understood. Accordingly, effective therapeutic strategies to stop the progression of RP and/or restore vision have yet to be established. The current study examines mechanisms of cell death in two models of RP that affect genes in visual cycle: Pro23His (P23H) rat and rd1 mice. The P23H transgenic albino rat ..

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