Journal article

Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import

Kylie M Wagstaff, Stephen Headey, Sushama Telwatte, David Tyssen, Anna C Hearps, David R Thomas, Gilda Tachedjian, David A Jans

CELLULAR MICROBIOLOGY | WILEY | Published : 2019

Abstract

Human immunodeficiency virus (HIV) continues to be a major contributor to morbidity and mortality worldwide, particularly in developing nations where high cost and logistical issues severely limit the use of current HIV therapeutics. This, combined HIV's high propensity to develop resistance, means that new antiviral agents against novel targets are still urgently required. We previously identified novel anti-HIV agents directed against the nuclear import of the HIV integrase (IN) protein, which plays critical roles in the HIV lifecycle inside the cell nucleus, as well as in transporting the HIV preintegration complex (PIC) into the nucleus. Here we investigate the structure activity relatio..

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University of Melbourne Researchers