Neural substrates of a schizotypal spectrum in typically-developing children: Further evidence of a normal-pathological continuum
David W Evans, Andrew M Michael, Mirko Ularevic, Laina G Lusk, Julia M Buirkle, Gregory J Moore
BEHAVIOURAL BRAIN RESEARCH | ELSEVIER SCIENCE BV | Published : 2016
Schizophrenia represents the extreme end of a distribution of traits that extends well into the general population. Using a recently developed measure of psychotic-like traits in children, we examined the neural substrates of psychotic (and other psychiatric) symptoms using structural magnetic resonance imaging (MRI). Twenty-eight typically-developing children (14 males) between the ages of 6-17 years underwent a 3T MRI scan. Parents completed the Psychiatric and Schizotypal Inventory for Children. Results revealed that caudate, amygdala, hippocampal and middle temporal gyrus volumes were associated with quantitative dimensions of psychiatric traits. Furthermore, results suggest a differenti..View full abstract
This research was supported by the Bucknell-Geisinger Research Initiative (BGRI) awarded to DWE and GJM.