Journal article

Metabolic patterns and seizure outcomes following anterior temporal lobectomy

Varduhi Cahill, Benjamin Sinclair, Charles B Malpas, Anne M McIntosh, Zhibin Chen, Lucy E Vivash, Marie F O'Shea, Sarah J Wilson, Patricia M Desmond, Salvatore U Berlangieri, Rodney J Hicks, Christopher C Rowe, Andrew P Morokoff, James A King, Gavin C Fabinyi, Andrew H Kaye, Patrick Kwan, Samuel F Berkovic, Terence J O'Brien

ANNALS OF NEUROLOGY | WILEY | Published : 2019


OBJECTIVE: We investigated the relationship between the interictal metabolic patterns, the extent of resection of 18 F-fluorodeoxyglucose positron emission tomography (18 FDG-PET) hypometabolism, and seizure outcomes in patients with unilateral drug-resistant mesial temporal lobe epilepsy (MTLE) following anterior temporal lobe (TL) resection. METHODS: Eighty-two patients with hippocampal sclerosis or normal magnetic resonance imaging (MRI) findings, concordant 18 FDG-PET hypometabolism, and at least 2 years of postoperative follow-up were included in this 2-center study. The hypometabolic regions in each patient were identified with reference to 20 healthy controls (p < 0.005). The resected..

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