Journal article

Informal genomic surveillance of regional distribution of Salmonella Typhi genotypes and antimicrobial resistance via returning travellers

Danielle Ingle, Satheesh Nair, Hassan Hartman, Philip Ashton, Zoe Dyson, Martin Day, Joanne Freedman, Marie Chattaway, Kathryn Holt, Timothy Dallman

Published : 2019


Abstract Salmonella enterica serovar Typhi ( S. Typhi) is the causative agent of typhoid fever, a systemic human infection with a burden exceeding 20 million cases each year that occur disproportionately among children in low and middle income countries. Antimicrobial therapy is the mainstay for treatment, but resistance to multiple agents is common. Here we report genotypes and antimicrobial resistance (AMR) determinants detected from routine whole-genome sequencing (WGS) of 533 S . Typhi isolates referred to Public Health England between April 2014 and April 2017, 488 (92%) of which had accompanying patient travel information obtained via an enhanced surveillance questionnaire. The majorit..

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