Transition state characteristics during cell differentiation
Rowan D Brackston, Eszter Lakatos, Michael PH Stumpf
PLOS COMPUTATIONAL BIOLOGY | PUBLIC LIBRARY SCIENCE | Published : 2018
Models describing the process of stem-cell differentiation are plentiful, and may offer insights into the underlying mechanisms and experimentally observed behaviour. Waddington's epigenetic landscape has been providing a conceptual framework for differentiation processes since its inception. It also allows, however, for detailed mathematical and quantitative analyses, as the landscape can, at least in principle, be related to mathematical models of dynamical systems. Here we focus on a set of dynamical systems features that are intimately linked to cell differentiation, by considering exemplar dynamical models that capture important aspects of stem cell differentiation dynamics. These model..View full abstract
Awarded by Biotechnology and Biological Sciences Research Council (BBSRC)
EL gratefully acknowledges support through a SchroEdinger Fellowship from Imperial College London. RDB and MPHS are funded from the Biotechnology and Biological Sciences Research Council (BBSRC) through grant BB/G020434/1. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.