Common genetic variation drives molecular heterogeneity in human iPSCs
Helena Kilpinen, Angela Goncalves, Andreas Leha, Vackar Afzal, Kaur Alasoo, Sofie Ashford, Sendu Bala, Dalila Bensaddek, Francesco Paolo Casale, Oliver JC Ulley, Petr Danecek, Adam Faulconbridge, Peter W Harrison, Annie Kathuria, Davis McCarthy, Shane A McCarthy, Ruta Meleckyte, Yasin Memari, Nathalie Moens, Filipa Soares Show all
Nature | NATURE PUBLISHING GROUP | Published : 2017
Awarded by Wellcome Trust
Awarded by UK Medical Research Council
Awarded by MRC eMedLab Medical Bioinformatics career development award from the UK Medical Research Council
This work was funded with a strategic award from the Wellcome Trust and UK Medical Research Council (WT098503). We thank the staff in the Cellular Genetics and Phenotyping and Sequencing core facilities at the Wellcome Trust Sanger Institute. Work at the Wellcome Trust Sanger Institute was further supported by Wellcome Trust grant WT090851. H.K. is supported by a MRC eMedLab Medical Bioinformatics career development award from the UK Medical Research Council (MR/L016311/1). F.M.W. acknowledges financial support from the Department of Health via the NIHR Biomedical Research Centre award to Guy's & St Thomas' National Health Service Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust. We acknowledge the participation of all NIHR Cambridge BioResource volunteers, and thank the NIHR Cambridge BioResource centre staff for their contribution. We thank the National Institute for Health Research and NHS Blood and Transplant. The NIHR/Wellcome Trust Cambridge Clinical Research Facility supported the volunteer recruitment. We acknowledge Life Science Technologies Corporation as the provider of Cytotune. We thank F.-J. Muller for insights regarding the PluriTest method, and the GTEx consortium for making raw data and intermediate results available.