Co-circulation of Multidrug-resistant Shigella Among Men Who Have Sex With Men in Australia
Danielle J Ingle, Marion Easton, Mary Valcanis, Torsten Seemann, Jason C Kwong, Nicola Stephens, Glen P Carter, Anders Goncalves da Silva, James Adamopoulos, Sarah L Baines, Kathryn E Holt, Eric PF Chow, Christopher K Fairley, Marcus Y Chen, Martyn D Kirk, Benjamin P Howden, Deborah A Williamson
Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2019
Background: In urban Australia, the burden of shigellosis is either in returning travellers from shigellosis-endemic regions, or in men who have sex with men (MSM). Here, we combine genomic data with comprehensive epidemiological data on sexual exposure and travel to describe the spread of multidrug-resistant Shigella lineages. Methods: A population-level study of all cultured Shigella isolates in the state of Victoria, Australia was undertaken from 1 January 2016 through to 31 March 2018. Antimicrobial susceptibility testing, whole genome sequencing (WGS) and bioinformatic analysis of 545 Shigella isolates was performed at the Microbiological Diagnostic Unit Public Health Laboratory (MDU PH..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (Project Grant number GNT1147735).