Mediation of the Relationship between Endovascular Therapy and Functional Outcome by Follow-up Infarct Volume in Patients with Acute Ischemic Stroke

AMM Boers; IGH Jansen; S Brown; HF Lingsma; LFM Beenen; TG Devlin; LS Román; JH Heo; M Ribó; MA Almekhlafi; DS Liebeskind; J Teitelbaum; P Cuadras; R Du Mesnil De Rochemont; M Beaumont; MM Brown; AJ Yoo; GA Donnan; JL Mas; C Oppenheim; RJ Dowling; T Moulin; N Agrinier; DK Lopes; L Aja Rodríguez; KCJ Compagne; FS Al-Ajlan; J Madigan; GW Albers; S Soize; J Blasco; SM Davis; RG Nogueira; A Dávalos; BK Menon; A Van Der Lugt; KW Muir; YBWEM Roos; P White; PJ Mitchell; AM Demchuk; WH Van Zwam; TG Jovin; RJ Van Oostenbrugge; DWJ Dippel; BCV Campbell; F Guillemin; S Bracard; MD Hill; M Goyal; HA Marquering; CBLM Majoie

Journal article

Mediation of the Relationship between Endovascular Therapy and Functional Outcome by Follow-up Infarct Volume in Patients with Acute Ischemic Stroke

AMM Boers, IGH Jansen, S Brown, HF Lingsma, LFM Beenen, TG Devlin, LS Román, JH Heo, M Ribó, MA Almekhlafi, DS Liebeskind, J Teitelbaum, P Cuadras, R Du Mesnil De Rochemont, M Beaumont, MM Brown, AJ Yoo, GA Donnan, JL Mas, C Oppenheim Show all

JAMA Neurology | Published : 2019

DOI: 10.1001/jamaneurol.2018.3661

Abstract

Importance: The positive treatment effect of endovascular therapy (EVT) is assumed to be caused by the preservation of brain tissue. It remains unclear to what extent the treatment-related reduction in follow-up infarct volume (FIV) explains the improved functional outcome after EVT in patients with acute ischemic stroke. Objective: To study whether FIV mediates the relationship between EVT and functional outcome in patients with acute ischemic stroke. Design, Setting, and Participants: Patient data from 7 randomized multicenter trials were pooled. These trials were conducted between December 2010 and April 2015 and included 1764 patients randomly assigned to receive either EVT or standard c..

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University of Melbourne Researchers

Geoffrey Donnan Author

Richard Dowling Author

Stephen Davis Author

Peter Mitchell Author

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Grants

Funding Acknowledgements

The Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials collaboration was funded by Medtronic through an unrestricted grant to the University of Calgary.