Selective antagonist activity of 5-aminohex-2-enedioic acid on amino acid excitation of cat spinal neurones

Abstract

D- and L-5-aminohex-2-enedioic acid (AHED) and the DL-2-bromo derivative, which are conformationally restricted analogues of the excitatory amino acid antagonist D-α-aminoadipic acid (DαAA), were tested microelectrophoretically on cat spinal neurones. D-AHED reduced the excitatory action of N-methyl-D-aspartate (NMDA) to a greater extent than that of L-glutamate and the potency of this action was a half to a third that of DαAA. The DL-2-bromo derivative excited neurones, an effect greater than that of L-glutamate and not blocked by either DαAA or L-glutamic acid diethyl ester. © 1980.