Chytridiomycosis causes catastrophic organism-wide metabolic dysregulation including profound failure of cellular energy pathways

Grants

Funding Acknowledgements

We thank P. Harlow, M. McFadden, D. Hunter and B. Scheele for assistance with logistics for the clinical experiment and species' insights. We also thank C. Rawlinson and H. Wong for valuable technical assistance towards GC-MS analyses. This work was jointly funded by the US Fish and Wildlife Service - Wildlife Without Borders program and the IUCN Amphibian Specialist Group Seed grants program. Metabolomics Australia is a Bioplatforms Australia (BPA) funded initiative. JPAG was supported through BPA. LG and LB were supported by Australian Research Council grants FT100100375, DP120100811 and LP110200240. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Additional Supporting Information may be found online for this article. Grogan et al. describes the underlying study and preparatory methodology in detail and presents the raw metabolomics data. Also see: Grogan, L. F. et al. (2018) Dryad Digital Repository (https://datadryad.org//resource/doi:10.5061/dryad.t1p7c), and Gummer, J. & Grogan, L. (2018) MetaboLights MTBLS457 (https://www.ebi.ac.uk/metabolights/MTBLS457).