Journal article

Molecular epidemiology of influenza A (H5N1) viruses, Bangladesh, 2007-2011

Md Ahasanul Hoque, Hein Min Tunh, Mohammad Mahmudul Hassan, Shahneaz Ali Khan, SKM Azizul Islam, Md Nurul Islam, Md Giasuddin, TABM Muzaffar Goni Osmani, Ariful Islam, Ronald Norman Thornton, Graham William Burgess, Lee Francis Skerratt, Paul Selleck, Edgar Brun, Nitish Chandra Debnatha, Frederick Chi-Ching Leung



To investigate the origins, evolution and patterns of spread of HPAI H5N1 outbreaks in Bangladesh, we performed a phylogenetic reconstruction analysis using Bayesian methods. The analysis was conducted using 81 hemagglutinin (HA) gene sequences from the H5N1 viruses isolated in Bangladesh from 2007 to 2011, together with 264 publicly available HA sequences of clade 2.2, 2.3.2 and 2.3.4 retrieved from GenBank. Our study provides evidence that clade 2.2.2 viruses that caused outbreaks in Bangladesh were lineages independent from the viruses introduced earlier into India. Furthermore, the Bangladesh clade 2.2.2 descendents subsequently spread to India and Bhutan. This has implications for avian..

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University of Melbourne Researchers


Funding Acknowledgements

Authors would like to thank to the Department of Livestock Services and National Reference Laboratory for Avian Influenza, Bangladesh Livestock Research Institute for their viral isolation and disease control. This study was partially supported by a Bioinformatics Center fund from Nanjing Agricultural University.