Journal article

Regional variation in percutaneous absorption in the tree frog Litoria caerulea

Victoria K Llewelyn, Lee Berger, Beverley D Glass

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | ELSEVIER SCIENCE BV | Published : 2018

Abstract

Frog skin structure and physiology differs between skin regions, however little is known about how these differences affect transdermal absorption of chemicals. Further, no information is available regarding how the relative lipophilicity of a chemical influences its transdermal pharmacokinetics in frog skin. This study investigated the in vitro percutaneous absorption of three model chemicals - benzoic acid, caffeine, and ibuprofen - through dorsal and ventral skin of the tree frog Litoria caerulea. Flux was significantly higher through the ventral skin for all chemicals. Relative lipophilicity affected flux differently in different skin regions. These differences are likely due to signific..

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University of Melbourne Researchers