Journal article
The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression
AT Amare, KO Schubert, F Tekola-Ayele, YH Hsu, K Sangkuhl, G Jenkins, RM Whaley, P Barman, A Batzler, RB Altman, V Arolt, J Brockmöller, CH Chen, K Domschke, DK Hall-Flavin, CJ Hong, A Illi, Y Ji, O Kampman, T Kinoshita Show all
Journal of Neural Transmission | SPRINGER WIEN | Published : 2019
Abstract
Selective serotonin reuptake inhibitors (SSRIs) are first-line antidepressants for the treatment of major depressive disorder (MDD). However, treatment response during an initial therapeutic trial is often poor and is difficult to predict. Heterogeneity of response to SSRIs in depressed patients is partly driven by co-occurring somatic disorders such as coronary artery disease (CAD) and obesity. CAD and obesity may also be associated with metabolic side effects of SSRIs. In this study, we assessed the association of CAD and obesity with treatment response to SSRIs in patients with MDD using a polygenic score (PGS) approach. Additionally, we performed cross-trait meta-analyses to pinpoint gen..
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Awarded by National Institutes of Health
Funding Acknowledgements
The ISPC study was supported by the NIH/NIGMS grant R24 GM61374, NIH/NCRR/NCATS CTSA grant number UL1 RR024150, Thailand Research Fund (TRF), Thailand Center of Excellence for Life Sciences (TCELS), National Center for Genetic Engineering and Biotechnology (BIOTEC), Tampere University Hospital Research Fund, the German Ministry of research and education in the German lead project on pharmacogenetic diagnostics grants in 2000-2004, grants from SENSHIN Medical Research Foundation and Grant-in-Aid for Scientific Research (KAKENHI), grants from the National Research Program for Genomic Medicine (NSC 98-3112-B-400-011, NSC 99-3112-B-400-003 and NSC 100-3112-B-400-015), the National Science Council (NSC 97-2314-B-400-001-MY3 and NSC 100-2314-B-400-002-MY3), the National Health Research Institutes, Taiwan (MD-095-PP-01, MD-095-PP-02, MD-097-PP-14, PH-098-PP-41, PH-098-PP-46, PH-098-PP-38, PH-098, 99-PP-42, PH-100-PP-37) and the Taiwan Psychiatric Research Network (PH-98, 99, 100-SP-11). The "Sequenced Treatment Alternatives to Relieve Depression" (STAR*D) study was supported by NIMH Contract # N01MH90003 to the University of Texas Southwestern Medical Center. The ClinicalTrials.gov identifier is NCT00021528.