White blood cell profiles in amphibians help to explain disease susceptibility following temperature shifts
Sasha E Greenspan, Deborah S Bower, Rebecca J Webb, Lee Berger, Donna Rudd, Lin Schwarzkopf, Ross A Alford
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | ELSEVIER SCI LTD | Published : 2017
Temperature variability, and in particular temperature decreases, can increase susceptibility of amphibians to infections by the fungus Batrachochytrium dendrobatidis (Bd). However, the effects of temperature shifts on the immune systems of Bd-infected amphibians are unresolved. We acclimated frogs to 16 °C and 26 °C (baseline), simultaneously transferred them to an intermediate temperature (21 °C) and inoculated them with Bd (treatment), and tracked their infection levels and white blood cell profiles over six weeks. Average weekly infection loads were consistently higher in 26°C-history frogs, a group that experienced a 5 °C temperature decrease, than in 16°C-history frogs, a group that ex..View full abstract
Awarded by Australian Research Council
This work was supported by a Discovery Grant from the Australian Research Council (grant number DP130101635) to RAA and LS.