Journal article

Weekly cholecalciferol supplementation results in significant reductions in infection risk among the vitamin D deficient: Results from the CIPRIS pilot RCT

S Simpson, I Van Der Mei, N Stewart, L Blizzard, P Tettey, B Taylor

BMC Nutrition | Springer Science and Business Media LLC | Published : 2015

Abstract

Background: Observational studies suggest vitamin D deficiency may contribute to the risk of acute infections. We undertook a randomised controlled trial (RCT) of cholecalciferol supplementation as an intervention against acute infections. Methods: A cohort of 34 healthy adults was randomised to 20,000 IU/week cholecalciferol or identical placebo and followed for 17 weeks during winter 2012. Acute infections, defined as the occurrence of sustained (at least an hour) infection symptoms, either of severity 2/5 or greater or sustained over 24 h, were monitored by daily online symptom reporting, with potential infections assessed in clinic. No microbiological verification of symptoms was availab..

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