Journal article

Malaria parasite clearance rate regression: an R software package for a Bayesian hierarchical regression model

Saeed Sharifi-Malvajerdi, Feiyu Zhu, Colin B Fogarty, Michael P Fay, Rick M Fairhurst, Jennifer A Flegg, Kasia Stepniewska, Dylan S Small

MALARIA JOURNAL | BMC | Published : 2019

Abstract

BACKGROUND: Emerging resistance to anti-malarial drugs has led malaria researchers to investigate what covariates (parasite and host factors) are associated with resistance. In this regard, investigation of how covariates impact malaria parasites clearance is often performed using a two-stage approach in which the WWARN Parasite Clearance Estimator or PCE is used to estimate parasite clearance rates and then the estimated parasite clearance is regressed on the covariates. However, the recently developed Bayesian Clearance Estimator instead leads to more accurate results for hierarchial regression modelling which motivated the authors to implement the method as an R package, called "bhrcr". M..

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University of Melbourne Researchers