Journal article
Sex differences in severity of stroke in the INSTRUCT study: A meta-analysis of individual participant data
HT Phan, MJ Reeves, CL Blizzard, AG Thrift, DA Cadilhac, J Sturm, P Otahal, P Rothwell, Y Bejot, NL Cabral, P Appelros, J Kõrv, R Vibo, C Minelli, SL Gall
Journal of the American Heart Association | WILEY | Published : 2019
Abstract
Background-—Women have worse outcomes after stroke than men, and this may be partly explained by stroke severity. We examined factors contributing to sex differences in severity of acute stroke assessed by the National Institutes of Health Stroke Scale. Methods and Results-—We pooled individual participant data with National Institutes of Health Stroke Scale assessment (N=6343) from 8 population-based stroke incidence studies (1996–2014), forming part of INSTRUCT (International Stroke Outcomes Study). Information on sociodemographics, stroke-related clinical factors, comorbidities, and pre-stroke function were obtained. Within each study, relative risk regression using log-binominal modeling..
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Awarded by Stroke Association
Funding Acknowledgements
Chief investigators for each of the studies provided their data at no cost. Phan is supported by a Merle Weaver Postgraduate Scholarship (University of Tasmania). Gall is supported by a National Heart Foundation of Australia Future Leader Fellowship (FLF 100446). Reeves was supported by a Menzies Institute Visiting Scholars Program (Tasmania, Australia). The following authors received research fellowship funding from the National Health and Medical Research Council (NHMRC): Thrift (1042600), Cadilhac (co-funded Heart Foundation: 1063761) and CA (1081356). The NHMRC also provided support for the study conducted in Melbourne (154600, 307900), as did VicHealth and the Stroke Foundation (Australia). The Brazilian National Council for Scientific and Technological Development (CNPq) funded the research conducted in Joinville (grant number 402396/2013-8). The Dijon Stroke Registry is supported by InVS and INSERM. The Oxford Vascular Study is funded by the Wellcome Trust, Stroke Association, and the National Institute of Health Research Biomedical Research Centre, Oxford.