Journal article

Renal perfusion, oxygenation, and sympathetic nerve activity during volatile or intravenous general anaesthesia in sheep

Naoya Iguchi, Junko Kosaka, Lindsea C Booth, Yoko Iguchi, Roger G Evans, Rinaldo Bellomo, Clive N May, Yugeesh R Lankadeva

BRITISH JOURNAL OF ANAESTHESIA | ELSEVIER SCI LTD | Published : 2019

Abstract

BACKGROUND: Global and intra-renal perfusion and oxygenation may be affected by the choice of anaesthetic. We compared the effects of isoflurane with those of propofol and fentanyl on renal blood flow (RBF) and intra-renal perfusion and oxygenation, and assessed how these were associated with renal sympathetic nerve activity (RSNA). METHODS: A renal artery flow probe and laser Doppler and oxygen-sensing probes were surgically implanted in the renal medulla and cortex in 20 Merino ewes. RSNA was measured in 12 additional ewes. We compared the effects of volatile or i.v. anaesthesia on global RBF, renal oxygen delivery (RDO2), intra-renal perfusion, and RSNA with the non-anaesthetised state on..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Heart Foundation of Australia Future Leader Fellowship


Awarded by Jack Brockhoff Foundation


Funding Acknowledgements

National Health and Medical Research Council of Australia (1050672 to CNM and RGE); Victorian Government Operational Infrastructure Support Grant; National Heart Foundation of Australia Future Leader Fellowship (101853 to YRL); Early Career Medical Research Grant from the Jack Brockhoff Foundation (4178 to YRL).