A child with Klinefelter syndrome and both IgE-mediated food allergy and low proportion of naive Treg
Rachel Frederick, Peter Vuillermin, Mimi LK Tang, Anne-Louise Ponsonby, Elise Webster, Richard Saffery, Fiona Collier
CLINICAL CASE REPORTS | WILEY | Published : 2019
This case suggests a possible association between Klinefelter Syndrome and decreased regulatory T cells (Treg) cells, relating to an increased risk of allergic and autoimmune disorders in these patients. The immune phenotyping of the circulating FOXP3+ naive Treg populations in KS patients may help to indicate this predisposition.