Overcoming natural Wnt inhibition to optimize therapy
Natalie A Sims
NATURE REVIEWS RHEUMATOLOGY | NATURE PUBLISHING GROUP | Published : 2019
The Wnt signalling pathway is the target of current anabolic therapies for osteoporosis. Studies in 2018 have revealed more about endogenous control of Wnt-related signalling, including mechanisms of natural Wnt inhibition and new anabolic signalling pathways that could be harnessed to overcome the challenges posed by current therapies.
The work of the author is supported by the St Vincent's Institute Brenda Shanahan Fellowship and by the State Government of Victoria's Operational Infrastructure Scheme. The author thanks T. J. Martin for helpful discussions during the preparation of this work.