Journal article

Evaluation of the transferability of survival calculators for stage II/III colon cancer across healthcare systems

Robert N Jorissen, Matthew Croxford, Ian T Jones, Robyn L Wards, Nicholas J Hawkins, Peter Gibbs, Oliver M Sieber

International Journal of Cancer | WILEY | Published : 2019

Abstract

Adjuvant! Online Inc (A!O), the Memorial Sloan Kettering Cancer Center (MSKCC), MD Anderson (MDA) and Mayo Clinic (MC) provide calculators to predict survival probabilities for patients with resected early-stage colon cancer, trained on data from United States (US) patient cohorts or patients enrolled in international clinical trials. Limited data exist on the transferability of calculators across healthcare systems. Calculator transferability to Australian community practice was evaluated for 1,401 stage II/III patients. Calibration and discrimination were assessed for overall (OS), cancer-specific (CSS) or recurrence-free survival (RFS). The US patient cohort-based calculators, A!O, MSKCC ..

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Grants

Awarded by Cancer Australia


Awarded by National Health and Medical Research Council


Funding Acknowledgements

Grant sponsor: Cancer Australia; Grant number: APP1120882; Grant sponsor: National Health and Medical Research Council; Grant number: APP1136119; Grant sponsor: Victorian Government's Operational Infrastructure Support Program; Grant number: NA