Journal article

Comparison of invasive and non-invasive aortic wave intensity and wave power analyses in sheep

Remi Kowalski, Jonathan P Mynard, Joseph Smolich, Michael MH Cheung



OBJECTIVE: Wave intensity (WI) and wave power (WP) analyses are powerful approaches for assessing ventricular-vascular interactions and arterial dynamics using invasive and non-invasive methods. However, in vivo comparison of these methods for large arteries is lacking. This study assessed agreement, correlation and relative changes in wave size in invasive and non-invasive aortic WI/WP analyses, and associated sources of error. APPROACH: The proximal descending thoracic aorta (DTA) of nine wethers was instrumented with a micromanometer and perivascular transit-time flow probe to measure high-fidelity blood pressure (P) and flow (Q) for invasive WI/WP analyses at baseline and during haemodyn..

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Awarded by NHMRC

Awarded by Centre of Research Excellence

Awarded by Heart Kids

Funding Acknowledgements

This work was supported by a National Health and Medical Research Council (NHMRC) Postgraduate Scholarship to R Kowalski, Heart Kids Grant-in-aid G005, NHMRC Project grant 491246, Centre of Research Excellence 1060733, the Victorian Government's Operational Infrastructure Support Program, and RCH 1000 of the Royal Children's Hospital Foundation. J Mynard is supported by a co-funded Career Development Fellowship/Future Leader Fellowship from the NHMRC and National Heart Foundation of Australia.