With a Little Help from T Follicular Helper Friends: Humoral Immunity to Influenza Vaccination
Marios Koutsakos, Thi HO Nguyen, Katherine Kedzierska
JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2019
Influenza remains a global and unpredictable threat. Annual vaccination against influenza A and B viruses promotes the induction of Abs and memory B cells, which can provide strain-specific protection against subsequent infections. The formation of effective memory B cell and Ab responses is highly dependent on the germinal center reaction, a well-orchestrated process involving B cells and a specialized CD4+ T cell subset called T follicular helper (Tfh) cells. As Tfh cells predominantly reside within B cell follicles in secondary lymphoid organs, they are challenging to study in humans. Recent identification of a circulating counterpart of Tfh cells has allowed us to better understand the c..View full abstract
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Awarded by National Health and Medical Research Council
This work was supported by a Melbourne International Research Scholarship and Melbourne International Fee Remission Scholarship (to M.K.). K.K. is supported by a National Health and Medical Research Council Senior Research Fellowship Level B (1102792).