Application of genomic technologies to measure and monitor antibiotic resistance in animals
Jian-Qiang Su, Li Cui, Qing-Lin Chen, Xin-Li An, Yong-Guan Zhu
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | WILEY | Published : 2017
One of the richest reservoirs of antibiotic-resistant bacteria and genes, animal intestinal microbiota contributes to the spread of antibiotic resistance in the environment and, potentially, to human pathogens. Both culture-based genomic technology and culture-independent metagenomics have been developed to investigate the abundance and diversity of antibiotic resistance genes. The characteristics, strengths, limitations, and challenges of these genomic approaches are discussed in this review in the context of antibiotic resistance in animals. We also discuss the advances in single-cell genomics and its potential for surveillance of antibiotic resistance in animals.
Awarded by National Key Research and Development Plan
Awarded by Natural Science Foundation of China
Awarded by Knowledge Innovation Program of the Chinese Academy of Sciences
This project was supported by the National Key Research and Development Plan (2016YFD 0800205), the Natural Science Foundation of China (21210008), the Knowledge Innovation Program of the Chinese Academy of Sciences (IUEQN201504), and the Youth Innovation Promotion Association of the Chinese Academy of Sciences.