Cancer Chemopreventive Activity of Maslinic Acid: Suppression of COX-2 Expression and Inhibition of NF-kappa B and AP-1 Activation in Raji Cells
Yap Wei Hsum, Wong Teck Yew, Paul Lim Vey Hong, Khoo Kong Soo, Lim Saw Hoon, Yeo Chew Chieng, Lim Yang Mooi
PLANTA MEDICA | GEORG THIEME VERLAG KG | Published : 2011
Chronic inflammation is one of the predisposing factors for neoplastic transformation. Targeting inflammation through suppression of the pro-inflammatory pathway by dietary phytochemicals provides an important strategy for cancer prevention. Maslinic acid is a novel natural triterpenoid known to inhibit proliferation and induce apoptosis in some tumor cell lines. Although maslinic acid has cytotoxic and pro-apoptotic effects on cancer cells, the underlying mechanisms of its effects on the inflammatory pathway have yet to be elucidated. It has been reported that abnormal expression of pro-inflammatory enzyme cyclooxygenase-2 (COX-2) causes promotion of cellular proliferation, suppression of a..View full abstract
Awarded by MOSTI
The authors would like to express their deepest gratitude to the Universiti Tunku Abdul Rahman and the MOSTI e-science fund (00-02-11-SF0028) for financially supporting this project.