Journal article

An Empirical Comparison of Meta- and Mega-Analysis With Data From the ENIGMA Obsessive-Compulsive Disorder Working Group

Premika SW Boedhoe, Martijn W Heymans, Lianne Schmaal, Yoshinari Abe, Pino Alonso, Stephanie H Ameis, Alan Anticevic, Paul D Arnold, Marcelo C Batistuzzo, Francesco Benedetti, Jan C Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Rosa Calvo, Yuqi Cheng, Kang lk K Cho, Valentina Ciullo, Sara Dallaspezia Show all

FRONTIERS IN NEUROINFORMATICS | FRONTIERS MEDIA SA | Published : 2019

Abstract

Objective: Brain imaging communities focusing on different diseases have increasingly started to collaborate and to pool data to perform well-powered meta- and mega-analyses. Some methodologists claim that a one-stage individual-participant data (IPD) mega-analysis can be superior to a two-stage aggregated data meta-analysis, since more detailed computations can be performed in a mega-analysis. Before definitive conclusions regarding the performance of either method can be drawn, it is necessary to critically evaluate the methodology of, and results obtained by, meta- and mega-analyses. Methods: Here, we compare the inverse variance weighted random-effect meta-analysis model with a multiple ..

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Grants

Awarded by NIH BD2K award


Awarded by Hartmann Muller Foundation


Awarded by Dutch Organization for Scientific Research (NWO)


Awarded by Netherlands Society for Scientific Research (NWO-ZonMw VENI grant)


Awarded by Netherlands Society for Scientific Research (NWO-ZonMw AGIKO stipend)


Awarded by Netherlands Brain Foundation


Awarded by Deutsche Forschungsgemeinschaft (DFG)


Awarded by Marato TV3 Foundation grants


Awarded by South London and Maudsley Trust, London, UK


Awarded by Japanese Ministry of Education, Culture, Sports, Science, and Technology (MEXT KAKENHI)


Awarded by International OCD Foundation Research Award


Awarded by National Institutes of Mental Health


Awarded by Government of India


Awarded by Department of Science and Technology


Awarded by Wellcome-DBT India Alliance grant


Awarded by Carlos III Health Institute


Awarded by FEDER funds/European Regional Development Fund (ERDF), AGAUR


Awarded by Miguel Servet contract from the Carlos III Health Institute


Awarded by Italian Ministry of Health


Awarded by Swiss National Science Foundation


Awarded by Netherlands Organization for Scientific Research


Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

DS has received research grants and/or consultancy honoraria from Biocodex, Lundbeck, and Sun in the past 3 years. The ENIGMA-Obsessive Compulsive Disorder Working-Group gratefully acknowledges support from the NIH BD2K award U54 EB020403 (PI: PT) and Neuroscience Amsterdam, IPB-grant to LS and OvdH. Supported by the Hartmann Muller Foundation (No. 1460 to SB); the International Obsessive-Compulsive Disorder Foundation (IOCDF) Research Award to PG; the Dutch Organization for Scientific Research (NWO) (grants 912-02-050, 907-00-012, 940-37-018, and 916.86.038); the Netherlands Society for Scientific Research (NWO-ZonMw VENI grant 916.86.036 to OvdH; NWO-ZonMw AGIKO stipend 920-03-542 to Dr. de Vries), a NARSAD Young Investigator Award to OvdH, and the Netherlands Brain Foundation [2010(1)-50 to OvdH]; Oxfordshire Health Services Research Committee (OHSRC) (AJ); the Deutsche Forschungsgemeinschaft (DFG) (KO 3744/2-1 to KK); the Marato TV3 Foundation grants 01/2010 and 091710 to LL; the Wellcome Trust and a pump priming grant from the South London and Maudsley Trust, London, UK (Project grant no. 064846) to DM-C; the Japanese Ministry of Education, Culture, Sports, Science, and Technology (MEXT KAKENHI No. 16K19778 and 18K07608 to TN); International OCD Foundation Research Award 20153694 and an UCLA Clinical and Translational Science Institute Award (to EN); National Institutes of Mental Health grant R01MH081864 (to JO and JP) and grant R01MH085900 (to JO and JF); the Government of India grants to YR (SR/S0/HS/0016/2011) and JN (DST INSPIRE faculty grant -IFA12-LSBM-26) of the Department of Science and Technology; the Government of India grants to YR (No. BT/PR13334/Med/30/259/2009) and JN (BT/06/IYBA/2012) of the Department of Biotechnology; the Wellcome-DBT India Alliance grant to GV (500236/Z/11/Z); the Carlos III Health Institute (CP10/00604, PI13/00918, PI13/01958, PI14/00413/PI040829, PI16/00889); FEDER funds/European Regional Development Fund (ERDF), AGAUR (2017 SGR 1247 and 2014 SGR 489); a Miguel Servet contract (CPII16/00048) from the Carlos III Health Institute to CS-M; the Italian Ministry of Health (RC10-11-12-13-14-15A to GS); the Swiss National Science Foundation (No. 320030_130237 to SW); and the Netherlands Organization for Scientific Research (NWO VIDI 917-15-318 to GvW). Further we wish to acknowledge Nerisa Banaj, Ph.D., Silvio Conte, Sergio Hernandez B.A., Yu Jin Ressal and Alice Quinton.