Journal article

Metal-dependent inhibition of amyloid fibril formation: synergistic effects of cobalt-tannic acid networks

Wenjie Zhang, Andrew J Christofferson, Quinn A Besford, Joseph J Richardson, Junling Guo, Yi Ju, Kristian Kempe, Irene Yarovsky, Frank Caruso

NANOSCALE | ROYAL SOC CHEMISTRY | Published : 2019

Abstract

Metal-phenolic networks (MPNs) have received widespread interest owing to their modular incorporation of functional metal ions and phenolic ligands. However, the interaction between MPNs and biomolecules is still relatively unexplored. Herein, we studied the effects of MPN-coated gold nanoparticles on amyloid fibril formation (which is associated with Alzheimer's disease) as a function of the metal ion in the MPN systems. All coated particles examined inhibited amyloid formation, with cobalt(ii) MPN-coated particles exhibiting the highest inhibition activity (90%). Molecular dynamics simulations and quantum mechanics calculations suggested that the geometry of the exposed cobalt coordination..

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Grants

Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship


Awarded by NHMRC-ARC Dementia Research Development Fellowship


Funding Acknowledgements

This research was conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). F. C. acknowledges the award of a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (APP1135806). K. K. gratefully acknowledges the award of an NHMRC-ARC Dementia Research Development Fellowship (APP1109945). This work was supported by resources provided by the Pawsey Supercomputing Centre with funding from the Australian Government and the Government of Western Australia, and the National Computational Infrastructure (NCI), which is supported by the Australian Government. This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at The University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). Part of this research was undertaken on the THz/FIR beamline at the Australian Synchrotron, part of the Australian Nuclear Science and Technology Organisation (ANSTO). We thank Dr Matthew Penna for useful discussions.