Journal article

Capacity To Utilize Raffinose Dictates Pneumococcal Disease Phenotype

Vikrant Minhas, Richard M Harvey, Lauren J McAllister, Torsten Seemann, Anna E Syme, Sarah L Baines, James C Paton, Claudia Trappetti

MBIO | AMER SOC MICROBIOLOGY | Published : 2019

Abstract

Streptococcus pneumoniae is commonly carried asymptomatically in the human nasopharynx, but it also causes serious and invasive diseases such as pneumonia, bacteremia, and meningitis, as well as less serious but highly prevalent infections such as otitis media. We have previously shown that closely related pneumococci (of the same capsular serotype and multilocus sequence type [ST]) can display distinct pathogenic profiles in mice that correlate with clinical isolation site (e.g., blood versus ear), suggesting stable niche adaptation within a clonal lineage. This has provided an opportunity to identify determinants of disease tropism. Genomic analysis identified 17 and 27 single nucleotide p..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by NHMRC Senior Principal Research Fellowship


Awarded by Australian Research Council DECRA Fellowship


Funding Acknowledgements

We acknowledge the contribution of the Antibiotic Resistant Sepsis Pathogens Framework Initiative consortium (https://data.bioplatforms.com/organization/pages/bpa-sepsis/consortium) in the generation of genome sequence data used in this publication. The Initiative is supported by funding from Bioplatforms Australia through the Australian Government National Collaborative Research Infrastructure Strategy (NCRIS). We also thank Kimberley McLean for assistance with animal experiments.This work was supported by National Health and Medical Research Council (NHMRC) Program Grant 1071659 and NHMRC Senior Principal Research Fellowship 1043070 to J.C.P. as well as Australian Research Council DECRA Fellowship DE140100963 and a University of Adelaide Beacon Fellowship to C.T. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.