The effects of a muscarinic receptor 1 gene variant on executive and nonexecutive cognition in schizophrenia spectrum disorders
Sean P Carruthers, Vanessa Cropley, Chad Bousman, Ian P Everall, Erica Neill, Christos Pantelis, Philip J Sumner, Eric J Tan, Kiymet Bozaoglu, Elizabeth HX Thomas, Tamsyn E Van Rheenen, Caroline T Gurvich, Susan L Rossell
PSYCHIATRY RESEARCH | ELSEVIER IRELAND LTD | Published : 2019
Individuals with schizophrenia who are homozygous at the c.267C > A (rs2067477) single nucleotide polymorphism within the muscarinic M1 receptor gene have been reported to perform less well on the Wisconsin Card Sorting Test (WCST). We investigated if rs2067477 genotype variation influenced WCST performance and non-executive cognition cross-diagnostically in a sample of 147 schizophrenia spectrum participants (SSD) and 294 healthy controls. We were unable to detect any significant differences in executive and non-executive cognitive performance across genotype. A broader genetic focus should be considered when investigating the association between the muscarinic system and cognition in SSD.