A continuum of T2* components: Flexible fast fraction mapping in sodium MRI

W Syeda; Y Blunck; S Kolbe; JO Cleary; LA Johnston

Journal article

A continuum of T2* components: Flexible fast fraction mapping in sodium MRI

W Syeda, Y Blunck, S Kolbe, JO Cleary, LA Johnston

Magnetic Resonance in Medicine | WILEY | Published : 2019

DOI: 10.1002/mrm.27659

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Abstract

Purpose: Parameter mapping in sodium MRI data is challenging due to inherently low SNR and spatial resolution, prompting the need to employ robust models and estimation techniques. This work aims to develop a continuum model of sodium T∗2 -decay to overcome the limitations of the commonly employed bi-exponential models. Estimates of mean T∗2 -decay and fast component fraction in tissue are emergent from the inferred continuum model. Methods: A closed-form continuum model was derived assuming a gamma distribution of T∗2 components. Sodium MRI was performed on four healthy human subjects and a phantom consisting of closely packed vials filled with an aqueous solution of varying sodium and agar..

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University of Melbourne Researchers

Warda Syeda Author

Yasmin Blunck Author

Leigh Johnston Author

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Grants

Awarded by Australian National Fabrication Facility

Funding Acknowledgements

This work was supported by Australian Research Council Discovery Project DP110103292. The authors acknowledge the technical and scientific support of the Australian National Imaging Facility at the Melbourne Brain Centre Imaging Unit.