Journal article

Breast tumour organoids: promising models for the genomic and functional characterisation of breast cancer

Charlotte Roelofs, Frederic Hollande, Richard Redvers, Robin L Anderson, Delphine Merino

BIOCHEMICAL SOCIETY TRANSACTIONS | PORTLAND PRESS LTD | Published : 2019

Abstract

Until recently, established cancer cell lines have been used extensively in breast cancer research, due largely to the difficulties associated with the manipulation and long-term maintenance in culture of primary tumour cells from patients. The recent development of organoid cultures has provided new opportunities to model and analyse patient samples, allowing the propagation of malignant cells under conditions that resemble the three-dimensional growth of breast tumours. They have proved efficacious in preserving the heterogeneity of primary samples and are emerging as a new model to further characterise the molecular features of breast cancer. Organoids formed from patient-derived cells ar..

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Grants

Awarded by National Health and Medical Research Council, Australia


Awarded by National Breast Cancer Foundation of Australia [NBCF]


Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

C.R. was supported by a graduate scholarship from La Trobe University, Australia. F.H. and D.M. were supported by the National Health and Medical Research Council, Australia [1049561 and 1101378]. R.L.A. was supported by the National Breast Cancer Foundation of Australia [NBCF grant IN-17-018 and senior research fellowship CF-09-01].