Journal article
Comparative bioinformatic analysis suggests that specific dauer-like signalling pathway components regulate Toxocara canis development and migration in the mammalian host
G Ma, T Wang, PK Korhonen, S Nie, GE Reid, AJ Stroehlein, AV Koehler, BCH Chang, A Hofmann, ND Young, RB Gasser
Parasites and Vectors | BMC | Published : 2019
Abstract
Background: Toxocara canis is quite closely related to Ascaris suum but its biology is more complex, involving a phase of arrested development (diapause or hypobiosis) in tissues as well as transplacental and transmammary transmission routes. In the present study, we explored and compared dauer-like signalling pathways of T. canis and A. suum to infer which components in these pathways might associate with, or regulate, this added complexity in T. canis. Methods: Guided by information for Caenorhabditis elegans, we bioinformatically inferred and compared components of dauer-like signalling pathways in T. canis and A. suum using genomic and transcriptomic data sets. In these two ascaridoids, ..
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Funding Acknowledgements
Funding from the National Health and Medical Research Council (NHMRC) of Australia, the Australian Research Council, Melbourne Water Corporation, Yourgene Bioscience and The University of Melbourne is gratefully acknowledged (RBG). NDY holds an NHMRC Career Development Fellowship (CDF1), and PKK holds an NHMRC Early Career Researcher Fellowship (ECRF). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.