Reducing Pup Litter Size Alters Early Postnatal Calcium Homeostasis and Programs Adverse Adult Cardiovascular and Bone Health in Male Rats
Jessica F Briffa, Rachael O'Dowd, Tania Romano, Beverly S Muhlhausler, Karen M Moritz, Mary E Wlodek
NUTRIENTS | MDPI | Published : 2019
The in utero and early postnatal environments play essential roles in offspring growth and development. Standardizing or reducing pup litter size can independently compromise long-term health likely due to altered milk quality, thus limiting translational potential. This study investigated the effect reducing litter size has on milk quality and offspring outcomes. On gestation day 18, dams underwent sham or bilateral uterine vessel ligation surgery to generate dams with normal (Control) and altered (Restricted) milk quality/composition. At birth, pups were cross-fostered onto separate dams with either an unadjusted or reduced litter size. Plasma parathyroid hormone-related protein was increa..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
This research was funded by the National Health and Medical Research Council (NHMRC) of Australia, grant numbers 208948 (M.E.W.) and 400003 (M.E.W. and K.M.M.). J.F.B. holds a Faculty of Medicine, Dentistry and Health Sciences Postdoctoral Fellowship at the University of Melbourne. K.M.M. was funded by a NHMRC Senior Research Fellowship.