Journal article

What Is Oligometastatic Prostate Cancer?

Michael Fraser, Bridget Koontz, Urban Emmenegger, Gert De Meerleer, Vincent Khoo, Felix Feng, Niall M Corcoran, Christopher M Hovens, Phuoc T Tran, Piet Ost, Paul C Boutros

European Urology Focus | ELSEVIER | Published : 2019

Abstract

Advanced prostate cancer patients can present with both widely metastatic or oligometastatic disease. Accumulating clinical evidence suggests that patients with oligometastatic disease have improved clinical responses from metastasis-directed therapy. This suggests that tumours that give rise to the oligometastatic state are distinct biologically and genetically from those that induce widely metastatic lesions. Detailed genomic analysis of the oligometastatic state will identify the molecular events that distinguish localised from metastatic disease, defining the molecular signatures of curability. The GAP6 consortium is well poised to address this question. PATIENT SUMMARY: In this report, ..

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