Preconditioning against renal ischaemia reperfusion injury: the failure to translate to the clinic
Dermot O'Kane, Graham S Baldwin, Damien M Bolton, Joseph J Ischia, Oneel Patel
JOURNAL OF NEPHROLOGY | SPRINGER HEIDELBERG | Published : 2019
Acute kidney injury (AKI) as a result of ischaemia-reperfusion represents a major healthcare burden worldwide. Mortality rates from AKI in hospitalized patients are extremely high and have changed little despite decades of research and medical advances. In 1986, Murry et al. demonstrated for the first time the phenomenon of ischaemic preconditioning to protect against ischaemia-reperfusion injury (IRI). This seminal finding paved the way for a broad body of research, which attempted to understand and ultimately harness this phenomenon for human application. The ability of preconditioning to limit renal IRI has now been demonstrated in multiple different animal models. However, more than 30 y..View full abstract
This work was in part supported by the Austin Health Medical Research Foundation and by The University of Melbourne.