Journal article

Colonization factors among enterotoxigenic Escherichia coli isolates from children with moderate-to-severe diarrhea and from matched controls in the Global Enteric Multicenter Study (GEMS)

Roberto M Vidal, Khitam Muhsen, Sharon M Tennant, Ann-Mari Svennerholm, Samba O Sow, Dipika Sur, Anita KM Zaidi, Abu SG Faruque, Debasish Saha, Richard Adegbola, M Jahangir Hossain, Pedro L Alonso, Robert F Breiman, Quique Bassat, Boubou Tamboura, Doh Sanogo, Uma Onwuchekwa, Byomkesh Manna, Thandavarayan Ramamurthy, Suman Kanungo Show all

PLoS Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2019

Abstract

BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) encoding heat-stable enterotoxin (ST) alone or with heat-labile enterotoxin (LT) cause moderate-to-severe diarrhea (MSD) in developing country children. The Global Enteric Multicenter Study (GEMS) identified ETEC encoding ST among the top four enteropathogens. Since the GEMS objective was to provide evidence to guide development and implementation of enteric vaccines and other interventions to diminish diarrheal disease morbidity and mortality, we examined colonization factor (CF) prevalence among ETEC isolates from children age <5 years with MSD and from matched controls in four African and three Asian sites. We also assessed strength of a..

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Grants

Awarded by Bill & Melinda Gates Foundation


Funding Acknowledgements

This work was supported by Grants 38874 and 38874.01 from the Bill & Melinda Gates Foundation; www.gatesfoundation.org; communicating author MML was the recipient of these grants. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.