The Clinical Case for the Integration of a Ketone Sensor as Part of a Closed Loop Insulin Pump System.
Melissa H Lee, Barbora Paldus, Balasubramanium Krishnamurthy, Sybil A McAuley, Rajiv Shah, Alicia J Jenkins, David N O'Neal
Journal of Diabetes Science and Technology | Published : 2019
Closed loop (CL) systems deliver insulin with a rapid onset and offset in action. Although favorable overall, the absence of a long-acting insulin increases the risk of diabetic ketoacidosis (DKA) which can occur with insulin delivery failure, acute illness, low carbohydrate diets, sodium glucose-linked transporter inhibitors, and high intensity exercise. A CL system relying entirely on interstitial glucose measurements may not provide an alert for DKA and many people with type 1 diabetes (T1D) do not carry a blood ketone meter and test-strips. Ketone sensing is theoretically feasible. A multianalyte platform incorporating a ketone sensor could provide an additional CL input without an incre..View full abstract